Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry)

Activity-guided fractionation of an EtOAc-soluble partition of the MeOH extract from the root bark of Berberis vulgaris L. (barberry), using a hydroxyl radical-scavenging assay, led to the isolation and identification of three phenolic compounds of a previously known structure, N-(p-trans-coumaroyl)...

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Bibliographic Details
Published in:Phytotherapy research 2008-07, Vol.22 (7), p.979-981
Main Authors: Tomosaka, Hideyuki, Chin, Young-Won, Salim, Angela A, Keller, William J, Chai, Heebyung, Kinghorn, A. Douglas
Format: Article
Language:English
Subjects:
(±)-lyoniresinol
Anisoles - analysis
Anisoles - pharmacology
antioxidant activity
Antioxidants - chemistry
Antioxidants - pharmacology
barberry
Berberidaceae
Berberis - chemistry
Berberis vulgaris
Biological and medical sciences
botanical dietary supplements
cannabisin G
Cell Line, Tumor
Cell Survival - drug effects
Chemical Fractionation
Chromatography, High Pressure Liquid
Coumaric Acids - analysis
Coumaric Acids - pharmacology
Cytoprotection
cytoprotective activity
Free Radical Scavengers
General pharmacology
Humans
Hydroxyl Radical
Medical sciences
Naphthalenes - analysis
Naphthalenes - pharmacology
Oxidative Stress - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenols - analysis
Phenols - pharmacology
Phytotherapy
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Roots - chemistry
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Summary:Activity-guided fractionation of an EtOAc-soluble partition of the MeOH extract from the root bark of Berberis vulgaris L. (barberry), using a hydroxyl radical-scavenging assay, led to the isolation and identification of three phenolic compounds of a previously known structure, N-(p-trans-coumaroyl)tyramine, cannabisin G and (±)-lyoniresinol. Of these, cannabisin G and (±)-lyoniresinol exhibited antioxidant activity in this bioassay. Furthermore, it was found that cannabisin G showed cytoprotective activity in cultured MCF-7 cells modulated by hydrogen peroxide. Copyright © 2008 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.2443