NADPH-Diaphorase-Containing Neurons in Cortex, Subcortical White Matter and Neostriatum Are Selectively Spared in Alzheimer’s Disease

To investigate the involvement of NADPH-diaphorase (NADPH-d)-containing neurons in Alzheimer’s disease (AD), NADPH-d enzyme histochemistry in vibratome sections was applied to the superior frontal and superior temporal cortex and the neostriatum in 5 AD and 6 aged control brains. Overall there was a...

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Bibliographic Details
Published in:Dementia and geriatric cognitive disorders 1999-11, Vol.10 (6), p.460-468
Main Authors: Tao, Zhen, van Gool, Dominique, Lammens, Martin, Dom, René
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - enzymology
Alzheimer Disease - pathology
Biological and medical sciences
Brain - enzymology
Brain - pathology
Cell Count
Cell Polarity - physiology
Cerebral Cortex - enzymology
Cerebral Cortex - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Frontal Lobe - enzymology
Frontal Lobe - pathology
Humans
Immunohistochemistry
Interneurons - enzymology
Interneurons - pathology
Male
Medical sciences
NADPH Dehydrogenase - metabolism
Neostriatum - enzymology
Neostriatum - pathology
Neurology
Neurons - enzymology
Neurons - pathology
Nitric Oxide Synthase - metabolism
Nitric Oxide Synthase Type I
Original Research Article
Temporal Lobe - enzymology
Temporal Lobe - pathology
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Summary:To investigate the involvement of NADPH-diaphorase (NADPH-d)-containing neurons in Alzheimer’s disease (AD), NADPH-d enzyme histochemistry in vibratome sections was applied to the superior frontal and superior temporal cortex and the neostriatum in 5 AD and 6 aged control brains. Overall there was a neuronal loss and atrophy in the cortex of AD. Despite slight morphological neuronal changes in the cortex of AD, we found no significant difference in the number of NADPH-d-positive neurons in both cortex and neostriatum between control and AD cases. These results provide further evidence for a selective preservation of NADPH-d neurons in AD. In order to check whether nNOS-immunoreactive neurons are identical to NADPH-d-positive neurons in the human brain, we examined the frontal and temporal cortex and neostriatum of normal human brains in serial cryostat sections. We found that nNOS-containing neurons paralleled NADPH-d-positive neurons in these brain regions.
ISSN:1420-8008
1421-9824
DOI:10.1159/000017190