Effect of low frequency ultrasound on the in vitro percutaneous absorption of clobetasol 17-propionate

The effect of low frequency ultrasound (20 kHz) on the permeation of clobetasol 17-propionate (CP) through skin (sonophoresis) was studied. The ultrasound was applied at either continuous or discontinuous modes and at different intensities. The results showed that low frequency ultrasound significan...

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Bibliographic Details
Published in:International journal of pharmaceutics 1999-11, Vol.191 (1), p.33-42
Main Authors: Fang, Jia-You, Fang, Chia-Lang, Sung, K.C., Chen, Hsiang-Yin
Format: Article
Language:English
Subjects:
Administration, Topical
Animals
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - pharmacokinetics
Biological and medical sciences
Cellulose
Clobetasol - administration & dosage
Clobetasol - analogs & derivatives
Clobetasol - pharmacokinetics
Clobetasol 17-propionate
Female
General pharmacology
Glucocorticoids
Humans
In Vitro Techniques
Medical sciences
Membranes, Artificial
Mice
Mice, Hairless
Percutaneous absorption
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Rats
Rats, Wistar
Skin - anatomy & histology
Skin - cytology
Skin - drug effects
Skin Absorption - physiology
Skin Temperature
Sonophoresis
Ultrasonics
Ultrasound
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Summary:The effect of low frequency ultrasound (20 kHz) on the permeation of clobetasol 17-propionate (CP) through skin (sonophoresis) was studied. The ultrasound was applied at either continuous or discontinuous modes and at different intensities. The results showed that low frequency ultrasound significantly enhanced the permeability of CP across hairless mouse skin in vitro. Delivering the same amount of ultrasonic energy in different modes of application markedly influenced the flux and skin residual of CP. The on/off discontinuous ultrasound had greater enhancement on CP permeation than the continuous ultrasound. The results of skin histopathology and permeation experiment using various membranes demonstrate that both disordering of stratum corneum and convective flow resulted from the cavitation effect were responsible for sonophoretic enhancement of CP. The permeation of CP through hair follicles and sweat ducts was susceptible to the application of ultrasound.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(99)00230-6