Regulation of Escherichia coli cell division genes ftsA and ftsZ by the two‐component system rcsC–rcsB

Genes rcsC and rcsB form a two‐component system in which rcsC encodes the sensor element and rcsB the regulator. In Escherichia coli, the system positively regulates the expression of the capsule operon, cps, and of the cell division gene ftsZ. We report the identification of the promoter and of the...

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Bibliographic Details
Published in:Molecular microbiology 1999-11, Vol.34 (3), p.442-450
Main Authors: Carballès, Fabrice, Bertrand, Claire, Bouché, Jean‐Pierre, Cam, Kaymeuang
Format: Article
Language:English
Subjects:
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Base Sequence
Cell Division - genetics
Cytoskeletal Proteins
Escherichia coli
Escherichia coli - genetics
Escherichia coli - growth & development
Escherichia coli - metabolism
Escherichia coli Proteins
ftsA gene
ftsZ gene
Gene Deletion
Gene Expression Regulation, Bacterial
Genes, Bacterial
Molecular Sequence Data
Multienzyme Complexes
Phosphoprotein Phosphatases
Promoter Regions, Genetic
Protein Kinases
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription, Genetic
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Summary:Genes rcsC and rcsB form a two‐component system in which rcsC encodes the sensor element and rcsB the regulator. In Escherichia coli, the system positively regulates the expression of the capsule operon, cps, and of the cell division gene ftsZ. We report the identification of the promoter and of the sequences required for rcsB‐dependent stimulation of ftsZ expression. The promoter, ftsA1p, located in the ftsQ coding sequence, co‐regulates ftsA and ftsZ. The sequences required for rcsB activity are immediately adjacent to this promoter.
ISSN:0950-382X
1365-2958
DOI:10.1046/j.1365-2958.1999.01605.x