Csp3-F bond activation by nucleophilic attack of the {Pt2S2} core assisted by non-covalent interactions

The high nucleophilicity of the sulfur atoms in [Pt(2)(dppp)(2)(micro-S)(2)] triggers a C-F activation process in 1,3-difluoro-2-propanol that leads to the [Pt(2)(dppp)(2)(micro-S)(micro-SCH(2)CH(OH)CH(2)F]F product through a S(N)2 mechanism, where the O-HF hydrogen bond established from the alcohol...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2008 (27), p.3130-3132
Main Authors: Nova, Ainara, Mas-Ballesté, Rubén, Ujaque, Gregori, González-Duarte, Pilar, Lledós, Agustí
Format: Article
Language:English
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Summary:The high nucleophilicity of the sulfur atoms in [Pt(2)(dppp)(2)(micro-S)(2)] triggers a C-F activation process in 1,3-difluoro-2-propanol that leads to the [Pt(2)(dppp)(2)(micro-S)(micro-SCH(2)CH(OH)CH(2)F]F product through a S(N)2 mechanism, where the O-HF hydrogen bond established from the alcohol group of the organic substrate is essential for assisting the departure of the fluoride anion.
ISSN:1359-7345
1364-548X
DOI:10.1039/b801889h