Effect of Dietary Lipid-Lowering Drugs upon Plasma Lipids and Egg Yolk Cholesterol Levels of Laying Hens

To evaluate the effect of lipid-lowering agents upon egg quality, reproductive performance, plasma lipids, and egg yolk cholesterol levels, 30-week-old Shaver laying hens were fed a basal diet (commercial ration) supplemented with 0.1% probucol (PROB), 0.025% gemfibrozil (GEMF), or lovastatin at 0.0...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 1999-11, Vol.47 (11), p.4731-4735
Main Authors: Mori, Agnes V, Mendonça, Cassio X, Santos, Cristiane O. F
Format: Article
Language:English
Subjects:
Animal productions
Animals
Anticholesteremic Agents - pharmacology
antilipemic agents
Biological and medical sciences
blood lipids
blood plasma
chemical composition
Chickens
cholesterol
Cholesterol - analysis
Dietary Supplements
dose response
Egg and egg product industries
egg yolk
Egg Yolk - chemistry
feed additives
Female
Food industries
Fundamental and applied biological sciences. Psychology
gemfibrozil
Gemfibrozil - pharmacology
hen feeding
hens
Lipids - blood
lovastatin
Lovastatin - pharmacology
probucol
Probucol - pharmacology
Terrestrial animal productions
Triglycerides - blood
Vertebrates
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Summary:To evaluate the effect of lipid-lowering agents upon egg quality, reproductive performance, plasma lipids, and egg yolk cholesterol levels, 30-week-old Shaver laying hens were fed a basal diet (commercial ration) supplemented with 0.1% probucol (PROB), 0.025% gemfibrozil (GEMF), or lovastatin at 0.0005% (LOV1), 0.001% (LOV2), or 0.0015% (LOV3) for a 12-week experimental period. It was observed that the supplementation of the drugs did not impair albumen and shell quality. Hen performance was not adversely affected. The depression in triglyceride concentrations approached statistical significance only in LOV2 (38.5%), and total cholesterol was significantly depressed in LOV2 (36.0%), LOV3 (36.8%), PROB (29.6%), and GEMF (30.4%) treatments. Egg cholesterol content, expressed per gram of yolk, was significant lowered in LOV1 (7.5%) and LOV3 (12.7%). Keywords: Cholesterol; egg yolk; lipid-lowering drugs; lipids; hens
ISSN:0021-8561
1520-5118
DOI:10.1021/jf990481+