A Case of Hypothyroidism with Brugada Electrocardiographic Waveforms

A 77-year-old man was diagnosed as having hypothyroidism. An electrocardiogram obtained at the time of the first examination revealed Brugada electrocardiographic waveforms in leads V1 to V3. When pilsicainide hydrochloride loading changed the waveforms of the electrocardiographic ST segment, this r...

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Bibliographic Details
Published in:Endocrine Journal 2008, Vol.55(3), pp.589-594
Main Authors: KITAHARA, Akira, HIRAI, Ritsuko, MATSUI, Yoshimi, IKEDA, Yukihiro, NAKAMURA, Hirotoshi
Format: Article
Language:English
Subjects:
Aged
Brugada electrocardiographic waveform
Brugada Syndrome - complications
Brugada Syndrome - diagnosis
Brugada Syndrome - physiopathology
Electrocardiography
Humans
Hypothyroidism
Hypothyroidism - complications
Hypothyroidism - diagnosis
Hypothyroidism - physiopathology
Male
Myocardial ion channel
Thyroid Gland - physiology
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Summary:A 77-year-old man was diagnosed as having hypothyroidism. An electrocardiogram obtained at the time of the first examination revealed Brugada electrocardiographic waveforms in leads V1 to V3. When pilsicainide hydrochloride loading changed the waveforms of the electrocardiographic ST segment, this result suggested an abnormality of the cardiac muscle sodium channels. The Brugada electrocardiographic waveforms disappeared with the normalization of thyroid function. This case is the first report ever of hypothyroidism that presented Brugada electrocardiographic waveforms. The results obtained in this case suggested that thyroid functions changed the waveforms of the electrocardiogram because of its effect on myocardial ion channels.
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.K07E-024