Central skeletal sarcoidosis mimicking metastatic disease

Sarcoidosis is a systemic disease that histologically typically shows non-caseating granulomas. The most common radiologic finding is hilar and mediastinal adenopathy. Patients with widely disseminated disease may show involvement of the peripheral appendicular skeleton in 1–13% of such cases. A pri...

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Bibliographic Details
Published in:Skeletal radiology 2008-08, Vol.37 (8), p.757-761
Main Authors: Talmi, Danit, Smith, Stacy, Mulligan, Michael E.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biopsy
Bone Diseases - diagnostic imaging
Bone Neoplasms - diagnostic imaging
Case Report
Diagnosis, Differential
Fluorodeoxyglucose F18
Humans
Imaging
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Medicine & Public Health
Middle Aged
Nuclear Medicine
Orthopedics
Osteoarticular system. Muscles
Pathology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Radiology
Radiopharmaceuticals
Sarcoidosis - diagnostic imaging
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Tomography, Emission-Computed
Tomography, X-Ray Computed
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Description
Summary:Sarcoidosis is a systemic disease that histologically typically shows non-caseating granulomas. The most common radiologic finding is hilar and mediastinal adenopathy. Patients with widely disseminated disease may show involvement of the peripheral appendicular skeleton in 1–13% of such cases. A primary skeletal presentation without other manifestations typical of the disease is rare. We present a case of sarcoidosis in a middle-aged Caucasian man in whom the disease presented with widespread lytic lesions in the axial skeleton and long bones, mimicking metastatic disease. There was no involvement of the peripheral skeleton, skin or lungs.
ISSN:0364-2348
1432-2161
DOI:10.1007/s00256-008-0479-7