Mechanisms of atrial fibrillation and flutter and implications for management

Both electrophysiologic and anatomical substrates are important in the generation and maintenance of atrial fibrillation. This review discusses the nature of re-entrant wavefronts in atrial fibrillation and the importance of anatomical structures, such as the pectinate muscles, in the generation and...

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Bibliographic Details
Published in:The American journal of cardiology 1999-11, Vol.84 (9), p.125-130
Main Authors: Chen, Peng-Sheng, Athill, Charles A, Wu, Tsu-Juey, Ikeda, Takanori, Ong, James J.C, Karagueuzian, Hrayr S
Format: Article
Language:English
Subjects:
Atrial Fibrillation - drug therapy
Atrial Fibrillation - physiopathology
Atrial Flutter - drug therapy
Atrial Flutter - physiopathology
Atrioventricular Node - drug effects
Atrioventricular Node - physiopathology
Cardiovascular disease
Electrocardiography
Electrocardiography - drug effects
Heart Atria - drug effects
Heart Atria - physiopathology
Humans
Medical supplies
Pharmacology
Tachycardia, Atrioventricular Nodal Reentry - drug therapy
Tachycardia, Atrioventricular Nodal Reentry - physiopathology
Transplants & implants
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Summary:Both electrophysiologic and anatomical substrates are important in the generation and maintenance of atrial fibrillation. This review discusses the nature of re-entrant wavefronts in atrial fibrillation and the importance of anatomical structures, such as the pectinate muscles, in the generation and maintenance of re-entry. The involvement of the pectinate muscle structure on intra-atrial re-entry may have significant implications for both ablation and pharmacologic management of patients with atrial fibrillation.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(99)00712-2