Tea Catechin Supplementation Increases Antioxidant Capacity and Prevents Phospholipid Hydroperoxidation in Plasma of Humans

The effect of green tea catechin supplementation on antioxidant capacity of human plasma was investigated. Eighteen healthy male volunteers who orally ingested green tea extract (254 mg of total catechins/subject) showed 267 pmol of epigallocatechin-3-gallate (EGCg) per milliliter of plasma at 60 mi...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 1999-10, Vol.47 (10), p.3967-3973
Main Authors: Nakagawa, Kiyotaka, Ninomiya, Manabu, Okubo, Tsutomu, Aoi, Nobuyuki, Juneja, Lekh Raj, Kim, Mujo, Yamanaka, Kenji, Miyazawa, Teruo
Format: Article
Language:English
Subjects:
Adult
Antioxidants - pharmacology
Biological and medical sciences
blood lipids
blood plasma
Catechin - blood
Catechin - pharmacology
Chromatography, High Pressure Liquid
Coffee, tea and other stimulative beverage industries
Dietary Supplements
epigallocatechin-3-gallate
extracts
flavanols
Food industries
Fundamental and applied biological sciences. Psychology
General pharmacology
Humans
ingestion
lipid peroxidation
Male
Medical sciences
oral administration
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phosphatidylcholine hydroperoxide
phosphatidylcholines
Phosphatidylcholines - blood
Plant Extracts - pharmacology
Reference Values
Tea
Time Factors
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Summary:The effect of green tea catechin supplementation on antioxidant capacity of human plasma was investigated. Eighteen healthy male volunteers who orally ingested green tea extract (254 mg of total catechins/subject) showed 267 pmol of epigallocatechin-3-gallate (EGCg) per milliliter of plasma at 60 min after administration. The plasma phosphatidylcholine hydroperoxide (PCOOH) levels attenuated from 73.7 pmol/mL in the control to 44.6 pmol/mL in catechin-treated subjects, being correlated inversely with the increase in plasma EGCg level. The results suggested that drinking green tea contributes to prevent cardiovascular disease by increasing plasma antioxidant capacity in humans. Keywords: Tea catechin; antioxidant; lipid peroxidation; phosphatidylcholine hydroperoxide; human plasma
ISSN:0021-8561
1520-5118
DOI:10.1021/jf981195l