Simple sequence repeats: genetic modulators of brain function and behavior

Simple sequence repeats (SSRs), sometimes described as genetic ‘stutters,’ are DNA tracts in which a short base-pair motif is repeated several to many times in tandem (e.g. CAGCAGCAG). These sequences experience frequent mutations that alter the number of repeats. Because SSRs are commonly located i...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2008-07, Vol.31 (7), p.328-334
Main Authors: Fondon, John W, Hammock, Elizabeth A.D, Hannan, Anthony J, King, David G
Format: Article
Language:English
Subjects:
Animals
Behavior
Behavior - physiology
Biological and medical sciences
Brain
Brain - physiology
Chronobiology
Deoxyribonucleic acid
DNA
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Genetics
Humans
Minisatellite Repeats - physiology
Mutation
Neurological disorders
Neurology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: nervous system and sense organs
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Summary:Simple sequence repeats (SSRs), sometimes described as genetic ‘stutters,’ are DNA tracts in which a short base-pair motif is repeated several to many times in tandem (e.g. CAGCAGCAG). These sequences experience frequent mutations that alter the number of repeats. Because SSRs are commonly located in promoters, untranslated regions and even coding sequences, such mutations can directly influence almost any aspect of gene function. Mutational expansion of certain triplet repeats is responsible for several hereditary neurodegenerative disorders, but SSR alleles can also contribute to normal variation in brain and behavioral traits. Here we review studies implicating SSRs not just in disease but also in circadian rhythmicity, sociosexual interaction, aggression, cognition and personality. SSRs can affect neuronal differentiation, brain development and even behavioral evolution.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2008.03.006