Variability of electrophrenic diaphragm twitch stimulation over time in normal subjects

Transcutaneous electrophrenic twitch stimulation is a potentially powerful way to assess diaphragm contractile function in response to interventions which may alter respiratory muscle strength and endurance. At present, the variability of the transdiaphragmatic twitch pressure (Pdi T) over a several...

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Bibliographic Details
Published in:Respiration physiology 1999-10, Vol.118 (1), p.39-47
Main Authors: Criner, Gerard J, Travaline, John M, Holt, Greg A, Bosse, Christopher G, Kelsen, Steven G
Format: Article
Language:English
Subjects:
Adult
Air breathing
Biological and medical sciences
Diaphragm - innervation
Diaphragm - physiology
Electric Stimulation - instrumentation
Electric Stimulation - methods
Fundamental and applied biological sciences. Psychology
Humans
Male
Mammals, humans
Methods, transcutaneous electrophrenic twitch stimulation
Muscle, diaphragm, transcutaneous stimulation
Phrenic Nerve - physiology
Pressure, transdiaphragmatic
Reference Values
Reproducibility of Results
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Skin - innervation
Vertebrates: respiratory system
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Summary:Transcutaneous electrophrenic twitch stimulation is a potentially powerful way to assess diaphragm contractile function in response to interventions which may alter respiratory muscle strength and endurance. At present, the variability of the transdiaphragmatic twitch pressure (Pdi T) over a several hour period is not well described. The present study examines the reproducibility of Pdi T amplitude and the twitch occlusion technique of assessing maximum transdiaphragmatic pressure (Pdi max) in seven normal adults stimulated intermittently every hour for a total 4-h period. In one subject, data were obtained on two occasions separated by a 2-month interval. Among all subjects, the Pdi T amplitude expressed as a percentage of the Pdi max was highly reproducible over 4 h (coefficient of variation 5.3). Peak Pdi T was inversely related to graded voluntary Pdi ( r=−0.0996) and the relationship was virtually identical over 4 h ( r=−0.999, P=0.96). These data show that Pdi T at functional residual capacity and the twitch occlusion relationship are highly reproducible.
ISSN:0034-5687
DOI:10.1016/S0034-5687(99)00057-2