Collagen dysplasia (cutaneous asthenia) in a cat

Hereditary collagen dysplasias comprise a complex group of connective-tissue disorders that result in the reduced tensile strength of affected tissues. These processes are called cutaneous asthenia in the skin of dogs and cats. We report here the case of a crossbred male cat, aged 6 months, that pre...

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Bibliographic Details
Published in:Veterinary pathology 1999-11, Vol.36 (6), p.603-606
Main Authors: Sequeira, J.L, Rocha, N.S, Bandarra, E.P, Figueiredo, L.M.A, Eugenio, F.R
Format: Article
Language:English
Subjects:
Animals
Asthenia - genetics
Asthenia - pathology
Asthenia - veterinary
case studies
Cat Diseases - genetics
Cat Diseases - pathology
Cats
collagen
Collagen - genetics
Collagen - ultrastructure
Collagen Diseases - genetics
Collagen Diseases - pathology
Collagen Diseases - veterinary
dysplasia
Fatal Outcome
genetic disorders
Histocytochemistry
histopathology
Male
Microscopy, Electron - veterinary
Pneumonia - veterinary
skin
Skin - pathology
Skin - ultrastructure
skin diseases
Skin Diseases - genetics
Skin Diseases - pathology
Skin Diseases - veterinary
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Summary:Hereditary collagen dysplasias comprise a complex group of connective-tissue disorders that result in the reduced tensile strength of affected tissues. These processes are called cutaneous asthenia in the skin of dogs and cats. We report here the case of a crossbred male cat, aged 6 months, that presented with two skin wounds in the region of the right thorax and right iliac tuberosity. The skin of these regions and of the animal's dorsum was hyperextensible, smooth to the touch, and easily torn with minor trauma. Microscopic examination of skin samples revealed reduced dermal connective tissue consisting of shortened and fragmented collagen fibers. Normal fibers were intermingled with altered fibers. Ultrastructural changes in collagen fibers included disorientation of fibrils within the same bundle, marked spacing differences, and variation in the diameter of transverse sections. The fibrils maintained the transverse striations characteristic of normal collagen.
ISSN:0300-9858
1544-2217
DOI:10.1354/vp.36-6-603