The clinical utility of 99mTc-HMPAO SPECT in Fahr’s disease

Fahr’s disease is a rare neurodegenerative syndrome, characterized by massive symmetrical intracerebral calcifications of the basal ganglia, dentate nuclei of the cerebellum, and the adjacent parenchyma. Computerized tomography (CT) is considerably more sensitive to detect these intracranial calcifi...

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Bibliographic Details
Published in:Annals of nuclear medicine 2008-06, Vol.22 (5), p.425-428
Main Authors: Ones, Tunc, Dede, Fuat, Gunal, Dilek, Ekinci, Gazanfer, Memis, Hatice, Erdil, Tanju Y., Inanir, Sabahat, Turoglu, Halil T.
Format: Article
Language:English
Subjects:
Adult
Brain - diagnostic imaging
Brain Diseases - diagnosis
Calcinosis - diagnostic imaging
Case Report
Female
Humans
Imaging
Medicine
Medicine & Public Health
Neurodegenerative Diseases - diagnosis
Nuclear Medicine
Radiology
Syndrome
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon - methods
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Summary:Fahr’s disease is a rare neurodegenerative syndrome, characterized by massive symmetrical intracerebral calcifications of the basal ganglia, dentate nuclei of the cerebellum, and the adjacent parenchyma. Computerized tomography (CT) is considerably more sensitive to detect these intracranial calcifications than other imaging modalities. The clinical, CT scan, and 99 m Tc- D,L -hexamethylpropylene amine oxime (99 m Tc-HMPAO) brain perfusion single-photon emission computerized tomography (SPECT) findings in a 42-year-old woman with Fahr’s disease are reported, and the clinical utility of 99 m Tc-HMPAO SPECT findings in Fahr’s disease is discussed in this article. In conclusion, 99 m Tc-HMPAO brain perfusion SPECT seems to be useful in the clinical approach to Fahr’s disease, and may provide more specific and clinically relevant information when compared with anatomical imaging.
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-007-0121-0