Acidic glycosaminoglycans of abdominal mucin in a case of pseudomyxoma peritonei caused by appendiceal cancer

Although the use of intraperitoneal mucolytic agents is useful in the management of pseudomyxoma peritonei, effective removal of mucin is difficult even by repeated mucolysis in cases with massive ascites. To establish mucolytic therapy as a further effective procedure, biochemical analysis of mucin...

Full description

Saved in:
Bibliographic Details
Published in:Digestive diseases and sciences 1999-11, Vol.44 (11), p.2231-2234
Main Authors: MIYASHITA, T, MURATA, K, HOSHINO, E, NISHIYA, H, ONO, Y, AKAOKA, I, KUNII, O
Format: Article
Language:English
Subjects:
Aged
Appendiceal Neoplasms - pathology
Biological and medical sciences
Cystadenocarcinoma, Mucinous - chemistry
Cystadenocarcinoma, Mucinous - secondary
Gastroenterology. Liver. Pancreas. Abdomen
Glycosaminoglycans - analysis
Humans
Hyaluronic Acid - analysis
Male
Medical sciences
Mucins - chemistry
Peritoneal Neoplasms - chemistry
Peritoneal Neoplasms - secondary
Pseudomyxoma Peritonei - metabolism
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although the use of intraperitoneal mucolytic agents is useful in the management of pseudomyxoma peritonei, effective removal of mucin is difficult even by repeated mucolysis in cases with massive ascites. To establish mucolytic therapy as a further effective procedure, biochemical analysis of mucin is required in greater detail. We reported here a case of pseudomyxoma peritonei caused by primary appendiceal cancer with biochemical analysis of mucin. The abdominal cavity in this case was filled with massive mucinous ascites. Although the mucolytic therapy was performed repeatedly, it was not effective in preventing mechanical ileus which was followed by surgical exclusion. Biochemical study of mucin showed that the mucin contained a small amount of hyaluronic acid, as characterized by electrophoretic study. These data led us to the hypothesis that the hyaluronic acid component plays a role in the pathogenesis of the replacement of mucin in the abdominal cavity.
ISSN:0163-2116
1573-2568
DOI:10.1023/A:1026648519050