mRNA quantification of C-type natriuretic peptide in brain areas of rodents

C-type natriuretic peptide (CNP) is regarded as an endothelium-derived vasodilator and might therefore have an important role in controlling vascular tone and remodeling. Because CNP also is expressed in the brain, it is considered to be a neurotransmitter. The present study compares expression leve...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1999-10, Vol.20 (10), p.1243-1245
Main Authors: Stepan, Holger, Leitner, Eszter, Siems, Wolf-Eberhard, Maul, Bjoern, Walther, Thomas
Format: Article
Language:English
Subjects:
Animals
Brain - metabolism
C-type natriuretic peptide (CNP)
Gene Expression
Mice
Mice, Inbred C57BL
Mouse brain
Natriuretic Peptide, C-Type - biosynthesis
Natriuretic Peptide, C-Type - genetics
Rat brain
Rats
Rats, Inbred WKY
RNA, Messenger
RNase-protection assay
Rodentia
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Summary:C-type natriuretic peptide (CNP) is regarded as an endothelium-derived vasodilator and might therefore have an important role in controlling vascular tone and remodeling. Because CNP also is expressed in the brain, it is considered to be a neurotransmitter. The present study compares expression levels of CNP mRNA in distinct areas of the mouse brain with the expression pattern in the rat brain. A distinct expression of CNP was found in all investigated areas with the exception of the mouse striatum. In both rodents, high CNP expression was detected in the tegmentum.
ISSN:0196-9781
1873-5169
DOI:10.1016/S0196-9781(99)00129-1