Comparative histopathology of radial artery versus internal thoracic artery and risk Factors for development of intimal hyperplasia and atherosclerosis

In this study, we examined the comparative histopathology, morphometry, and risk factors for the development of intimal hyperplasia and atherosclerosis in the radial artery (RA) and the internal thoracic artery (ITA). Paired specimens of RAs and ITAs, obtained from 150 patients who underwent CABG, w...

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Published in:Circulation (New York, N.Y.) N.Y.), 1999-11, Vol.100 (19), p.II139-II144
Main Authors: RUENGSAKULRACH, P, SINCLAIR, R, KOMEDA, M, RAMAN, J, GORDON, I, BUXTON, B
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Arteriosclerosis - etiology
Arteriosclerosis - pathology
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Female
Humans
Hyperplasia
Image Cytometry
Male
Medical sciences
Middle Aged
Radial Artery - pathology
Risk Factors
Thoracic Arteries - pathology
Tunica Intima - pathology
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Summary:In this study, we examined the comparative histopathology, morphometry, and risk factors for the development of intimal hyperplasia and atherosclerosis in the radial artery (RA) and the internal thoracic artery (ITA). Paired specimens of RAs and ITAs, obtained from 150 patients who underwent CABG, were evaluated with histopathology; 110 pairs of arteries were suitable for morphometric analysis. The severity of disease was evaluated on the basis of percentage of luminal narrowing, intimal thickness index, and intima-to-media ratio. Risk factors were determined with stepwise linear regression. Intimal hyperplasia was seen in 141 RAs (94%) and 103 ITAs (69%) (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.100.suppl_2.ii-139