Macrophages Behaving Badly: Infected Cells and Subversion of Immune Responses to Theileria annulata

The protozoan parasite Theileria annulata is the causative agent of the tick-borne disease tropical theileriosis, responsible for morbidity and mortality of cattle in many developing countries. Here, John Campbell and Roger Spooner discuss how the parasite might evade immune destruction during an ac...

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Bibliographic Details
Published in:Parasitology Today 1999, Vol.15 (1), p.10-16
Main Authors: Campbel, J.D.M., Spooner, R.L.
Format: Article
Language:English
Subjects:
activation
Analysis of the immune response. Humoral and cellular immunity
Animals
Biological and medical sciences
Cattle
Cell Line
Cytokines
Fundamental and applied biological sciences. Psychology
Fundamental immunology
gamma
IFN-g
Immunobiology
Interferon
macrophage
Macrophages - immunology
Macrophages - parasitology
Organs and cells involved in the immune response
T-cell
T-Lymphocytes - immunology
Theileria annulata
Theileria annulata - growth & development
Theileria annulata - immunology
Theileriasis - immunology
Theileriasis - parasitology
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Summary:The protozoan parasite Theileria annulata is the causative agent of the tick-borne disease tropical theileriosis, responsible for morbidity and mortality of cattle in many developing countries. Here, John Campbell and Roger Spooner discuss how the parasite might evade immune destruction during an acute primary infection. Theileria annulata macroschizont-infected macrophages act as over-efficient antigen-presenting cells within the infected draining lymph node. Infected cells activate CD4 + and CD8 + T cells abnormally, giving rise to a cascade of cytokine production. This altered immune response does not reject the parasitized cells, and might actively participate in the growth of the developing parasite.
ISSN:0169-4758
1873-1473
DOI:10.1016/S0169-4758(98)01359-3