Genetics of male subfertility: consequences for the clinical work-up

Major principles of genetic failures, chromosomal alterations and the most common syndromes associated with male subfertility should be taken into account before medical therapy and sophisticated techniques of assisted fertilization are applied to help a couple conceive. This review addresses the mo...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1999-09, Vol.14 (suppl-1), p.24-37
Main Authors: Küpker, Wolfgang, Schwinger, Eberhard, Hiort, Olaf, Ludwig, Michael, Nikolettos, Nikos, Schlegel, Peter N., Diedrich, Klaus
Format: Article
Language:English
Subjects:
androgen receptor
Biological and medical sciences
Chromosome Aberrations
chromosome disorders
Cystic Fibrosis Transmembrane Conductance Regulator - genetics
Gene Deletion
genetics
Gynecology. Andrology. Obstetrics
Humans
Infertility, Male - genetics
Male
Male genital diseases
male subfertility
Medical sciences
Mutation
Non tumoral diseases
Oligospermia - genetics
Receptors, Androgen - genetics
Y Chromosome
Y deletions
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Summary:Major principles of genetic failures, chromosomal alterations and the most common syndromes associated with male subfertility should be taken into account before medical therapy and sophisticated techniques of assisted fertilization are applied to help a couple conceive. This review addresses the most common genetic reasons for male subfertility or infertility with special regard to the importance for the clinical work-up in daily routine and the potential risks for the conceptus.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/14.suppl_1.24