Angiotensin II Stimulates Gene Expression of Cardiac Insulin-Like Growth Factor I and Its Receptor Through Effects on Blood Pressure and Food Intake

Angiotensin II (Ang II) is known to act as a growth factor and may be involved in cardiac remodeling. We have shown that insulin-like growth factor-I (IGF-I) is an autocrine mediator of growth responses to Ang II in vascular smooth muscle cells in vitro, and we hypothesized that IGF-I also serves as...

Full description

Saved in:
Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-11, Vol.34 (5), p.1053-1059
Main Authors: Brink, Marijke, Chrast, Jacqueline, Price, S Russ, Mitch, William E, Delafontaine, Patrick
Format: Article
Language:English
Subjects:
Angiotensin II - pharmacology
Animals
Antihypertensive Agents - pharmacology
Biological and medical sciences
Blood Pressure - drug effects
Cardiology. Vascular system
Eating - drug effects
Heart
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hypertrophy, Left Ventricular - etiology
Insulin-Like Growth Factor I - biosynthesis
Insulin-Like Growth Factor I - genetics
Insulin-Like Growth Factor I - pharmacology
Male
Medical sciences
Myocardium - metabolism
Rats
Rats, Sprague-Dawley
Receptor, IGF Type 1 - genetics
RNA, Messenger - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Angiotensin II (Ang II) is known to act as a growth factor and may be involved in cardiac remodeling. We have shown that insulin-like growth factor-I (IGF-I) is an autocrine mediator of growth responses to Ang II in vascular smooth muscle cells in vitro, and we hypothesized that IGF-I also serves as an important modulator of cardiovascular growth in vivo. To study the effect of Ang II on cardiac IGF-I, we infused rats for 3, 7, or 14 days with Ang II through osmotic minipumps. After 7 days, left ventricular mass normalized for body weight was increased by 20% (P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.34.5.1053