Individual kidney function in atherosclerotic nephropathy is not related to the presence of renal artery stenosis

Background. Atherosclerotic renovascular disease is increasingly recognized as an important cause of renal failure in patients over 60 years of age but the processes leading to renal dysfunction have not been defined. We have examined the relationship between renal artery stenosis and individual ren...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 1999-12, Vol.14 (12), p.2880-2884
Main Authors: Farmer, Christopher k. T., Cook, Gary j. R., Blake, Glen M., Reidy, John, Scoble, John E.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Arteriosclerosis - physiopathology
Biological and medical sciences
Female
Glomerular Filtration Rate
Humans
Kidney - physiopathology
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Prospective Studies
radioisotope scintigraphy
Renal Artery Obstruction - physiopathology
renovascular disease
Renovascular diseases
single kidney glomerular filtration rate
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Summary:Background. Atherosclerotic renovascular disease is increasingly recognized as an important cause of renal failure in patients over 60 years of age but the processes leading to renal dysfunction have not been defined. We have examined the relationship between renal artery stenosis and individual renal function in patients with atherosclerotic renal artery stenosis. Methods. In this prospective descriptive study over a 25-month period, we examined the relationship between the presence of renal artery stenosis and single kidney glomerular filtration rate (SKGFR). SKGFR was measured using a novel method of synchronous 51Chromium ethylenediamine tetraacetic acid glomerular filtration rate (51CrEDTA-GFR) and 99mTechnetium dimercaptosuccinic acid (99mTcDMSA) scintigraphy. We studied 79 patients with a mean age of 68.9 years (25.2–88.2), 44 males and 35 females. The mean age of the males was 70 years (60–80) and females 67 years (25.2–88.2). Results. We found that the precision of the SKGFR was 2 ml/min. For paired kidneys we found: (i) no significant difference between kidneys with stenosis (17.3 ml/min) compared to those without stenosis (13.6 ml/min) (P=0.22); (ii) kidneys with occluded renal arteries had significantly less function (2.6 ml/min) than those without occlusion (24.5 ml/min) (P
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/14.12.2880