The Role of Albendazole in Programmes to Eliminate Lymphatic Filariasis

Citing earlier advances in the treatment of lymphatic filariasis [particularly the effectiveness of single-dose diethylcarbamazine (DEC) in reducing microfilaraemia and its enhanced effectiveness when co-administered with single-dose ivermectin], Eric Ottesen, Mahroof Ismail and John Horton consider...

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Bibliographic Details
Published in:Parasitology today (Regular ed.) 1999-09, Vol.15 (9), p.382-386
Main Authors: Ottesen, E.A., Ismail, M.M., Horton, J.
Format: Article
Language:English
Subjects:
Albendazole
Albendazole - administration & dosage
Albendazole - therapeutic use
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Biological and medical sciences
Brugia malayi - drug effects
Diethylcarbamazine (DEC)
Diethylcarbamazine - administration & dosage
Diethylcarbamazine - therapeutic use
Elephantiasis, Filarial - drug therapy
Elephantiasis, Filarial - prevention & control
Elimination
Filaricides - administration & dosage
Filaricides - therapeutic use
Humans
Ivermectin
Ivermectin - administration & dosage
Ivermectin - therapeutic use
Lymphatic filariasis
Male
Medical sciences
Microfilariae - drug effects
Patient Compliance
Pharmacology. Drug treatments
Public Health
Treatment
Wuchereria bancrofti - drug effects
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Summary:Citing earlier advances in the treatment of lymphatic filariasis [particularly the effectiveness of single-dose diethylcarbamazine (DEC) in reducing microfilaraemia and its enhanced effectiveness when co-administered with single-dose ivermectin], Eric Ottesen, Mahroof Ismail and John Horton consider recent studies on the antifilarial activity of albendazole that have led to the current recommendations for its use in single-dose regimens in conjunction with either DEC or ivermectin for large-scale control/elimination programmes. Furthermore, the potential of albendazole as a macrofilaricide for treating individual patients with lymphatic filarial infections is emphasized as one of a number of important research questions that remain to be explored.
ISSN:0169-4758
1873-1473
DOI:10.1016/S0169-4758(99)01486-6