Ribavirin ameliorates experimental autoimmune encephalomyelitis in rats and modulates cytokine production

To determine the mechanism underlying ribavirin induced amelioration of experimental autoimmune encephalomyelitis (EAE), cytokine profiles were evaluated in draining lymph node (DLN) cell culture supernatants and spinal cord obtained from EAE and/or ribavirin-treated EAE Dark Agouti rats. Administra...

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Published in:International immunopharmacology 2008-09, Vol.8 (9), p.1282-1290
Main Authors: Lavrnja, Irena, Stojkov, Danijela, Bjelobaba, Ivana, Pekovic, Sanja, Dacic, Sanja, Nedeljkovic, Nadezda, Mostarica-Stojkovic, Marija, Stosic-Grujicic, Stanislava, Rakic, Ljubisav, Stojiljkovic, Mirjana
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - therapeutic use
Biological and medical sciences
Brain - pathology
Cells, Cultured
Central Nervous System - drug effects
Central Nervous System - metabolism
Cytokines
Cytokines - biosynthesis
EAE
Encephalomyelitis, Autoimmune, Experimental - drug therapy
Encephalomyelitis, Autoimmune, Experimental - metabolism
Encephalomyelitis, Autoimmune, Experimental - pathology
Female
Immunohistochemistry
Lymph Nodes - pathology
Medical sciences
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Pharmacology. Drug treatments
Rats
Ribavirin
Ribavirin - therapeutic use
Spinal Cord - pathology
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Summary:To determine the mechanism underlying ribavirin induced amelioration of experimental autoimmune encephalomyelitis (EAE), cytokine profiles were evaluated in draining lymph node (DLN) cell culture supernatants and spinal cord obtained from EAE and/or ribavirin-treated EAE Dark Agouti rats. Administration of ribavirin to EAE rats markedly affected the production of pro-inflammatory cytokines IFN-γ, IL-1β and TNF-α in DLN and spinal cord, thus shifting the balance towards the anti-inflammatory cytokines IL-10 and TGF-β. These findings suggest that ribavirin attenuates EAE by limiting cytokine-mediated immunoinflammatory events leading to CNS destruction. The conducted experiments provide rationale for ribavirin to be considered as a candidate drug in the development of new therapeutic strategies for the treatment of autoimmune diseases in humans, such as multiple sclerosis.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2008.05.008