Placental transfer of stobadine in rabbits

Stobadine, a pyridoindole antioxidant, was investigated for its placental transfer and distribution in New Zealand white rabbits on the 27th day of gestation. The concentrations of stobadine were determined in maternal and foetal organs (plasma, brain, heart) at 30, 60, 120, and 360 minutes after or...

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Bibliographic Details
Published in:Life sciences (1973) 1999-10, Vol.65 (18), p.2011-2014
Main Authors: Ujházy, E., Dubovický, M., Šoltés, L., Faberová, V., Zemánek, M., Gajdošík, A.
Format: Article
Language:English
Subjects:
Animals
antioxidant
Antioxidants - pharmacokinetics
Brain - metabolism
Carbolines - blood
Carbolines - pharmacokinetics
Female
Fetus - metabolism
Maternal-Fetal Exchange - physiology
Myocardium - metabolism
Placenta - metabolism
placental transfer
Pregnancy
rabbit
Rabbits
stobadine
Tissue Distribution
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Summary:Stobadine, a pyridoindole antioxidant, was investigated for its placental transfer and distribution in New Zealand white rabbits on the 27th day of gestation. The concentrations of stobadine were determined in maternal and foetal organs (plasma, brain, heart) at 30, 60, 120, and 360 minutes after oral administration of the drug in a dose of 5 mg/kg. The results obtained proved that after oral stobadine intake by rabbits at the stage of advanced pregnancy both maternal and foetal organs were under a certain drug level which could act protectively against oxidative stress — frequently occurring during late organogenesis, foetal stages and delivery, as well as during early postnatal development.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(99)00467-1