Epigenetic Programming of Phenotypic Variations in Reproductive Strategies in the Rat Through Maternal Care

Studies across multiple organisms reveal considerable phenotypic variation in reproductive tactics. In some species, this variation is associated with maternal effects in which variation in maternal investment results in stable individual differences in reproductive function. Recent studies with the...

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Bibliographic Details
Published in:Journal of neuroendocrinology 2008-06, Vol.20 (6), p.795-801
Main Authors: Cameron, N. M., Shahrokh, D., Del Corpo, A., Dhir, S. K., Szyf, M., Champagne, F. A., Meaney, M. J.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Epigenesis, Genetic
estrogen receptor alpha
Estrogen Receptor alpha - genetics
Estrogen Receptor alpha - metabolism
Female
Fundamental and applied biological sciences. Psychology
gonadotropin releasing
hormone
Maternal Behavior - physiology
medial preoptic area
Neurosecretory Systems - physiology
oxytocin
Phenotype
Rats
Reproduction - physiology
Sexual Behavior, Animal - physiology
Vertebrates: endocrinology
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Summary:Studies across multiple organisms reveal considerable phenotypic variation in reproductive tactics. In some species, this variation is associated with maternal effects in which variation in maternal investment results in stable individual differences in reproductive function. Recent studies with the rat suggest that maternal effects can alter the function of neuroendocrine systems associated with female sexual behaviour as well as maternal behaviour. These maternal effects appear to be mediated by epigenetic modifications at the promoter for oestrogen receptor alpha (ERα) and subsequent effects on gene expression. The tissue‐specific nature of such effects may underlie the co‐ordinated variation in multiple forms of reproductive function, resulting in distinct reproductive strategies.
ISSN:0953-8194
1365-2826
DOI:10.1111/j.1365-2826.2008.01725.x