Type I interferons and the Th1/Th2 paradigm

During the past year significant advances have been made in our understanding of the factors contributing to the differentiation of CD4 + T helper cell subsets. These have been driven, in part, by the realization that cytokines from the innate immune response, such as interleukin-12 (IL-12) and inte...

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Bibliographic Details
Published in:Developmental and Comparative Immunology 1999-10, Vol.23 (7), p.657-663
Main Authors: Sinigaglia, F., D’Ambrosio, D., Rogge, L.
Format: Article
Language:English
Subjects:
AIDS/HIV
Animals
CD4 antigen
Cell Division
Cytokine signalling
DNA-Binding Proteins - immunology
Humans
IL-12
Interferon
Interferon Type I - immunology
Interleukin-12 - immunology
Mice
Multiple sclerosis
Multiple Sclerosis - drug therapy
Multiple Sclerosis - immunology
Species Specificity
STAT4 Transcription Factor
Th1 cells
Th1 Cells - cytology
Th1 Cells - immunology
Th2 cells
Th2 Cells - cytology
Th2 Cells - immunology
Trans-Activators - immunology
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Summary:During the past year significant advances have been made in our understanding of the factors contributing to the differentiation of CD4 + T helper cell subsets. These have been driven, in part, by the realization that cytokines from the innate immune response, such as interleukin-12 (IL-12) and interferons (IFNs), play a critical role in T cell subset differentiation. This review covers some of the most recent data concerning the divergent role that IFNs have in the differentiation of human versus mouse T helper cell subsets. In this review we discuss the molecular basis for the specie-specific effect of type I IFN on the selective induction of Th1 type immune responses. Furthermore, since IFN-β is used in the treatment of multiple sclerosis (MS) we discuss the potential effects of such treatment and the value of the Th1/Th2 paradigm in MS.
ISSN:0145-305X
1879-0089
DOI:10.1016/S0145-305X(99)00039-7