Sensing of human plasma fibrinogen on polished, chemically etched and carbon treated titanium surfaces by diffractive optical element based sensor

Adsorption of human plasma fibrinogen (HPF) on 6 differently treated titanium samples (polished, polished and etched, and 4 titanium carbide coatings samples produced by using plasma-enhanced chemical vapour deposition (PECVD) method) is investigated by using diffractive optical element (DOE) sensor...

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Bibliographic Details
Published in:Optics express 2008-07, Vol.16 (14), p.10130-10140
Main Authors: Silvennoinen, Raimo, Vetterl, Vladimir, Hason, Stanislav, Tuononen, Heikki, Silvennoinen, Martti, Myller, Kari, Cvrcek, Ladislav, Vanek, Jiri, Prachar, Patrik
Format: Article
Language:English
Subjects:
Adsorption
Electrolytes
Equipment Design
Fibrinogen - analysis
Fibrinogen - chemistry
Humans
Models, Chemical
Models, Statistical
Nanoparticles
Nanotechnology - methods
Optics and Photonics
Surface Properties
Time Factors
Titanium - chemistry
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Summary:Adsorption of human plasma fibrinogen (HPF) on 6 differently treated titanium samples (polished, polished and etched, and 4 titanium carbide coatings samples produced by using plasma-enhanced chemical vapour deposition (PECVD) method) is investigated by using diffractive optical element (DOE) sensor. Permittivity (susceptibility) change and fluctuation in optical roughness (R(opt)) of treated titanium surface in the presence of background electrolyte without and with HPF molecules are sensed by using DOE sensor and optical ellipsometry. Correlation between transmitted light and thickness of molecule layer was found. The findings allow to sense temporal organization and severity of adsorption of nano-scale HPF molecules on polished, on polished and etched, and on titanium carbide surface.
ISSN:1094-4087
1094-4087
DOI:10.1364/OE.16.010130