Plasma Epstein-Barr viral load predicting response after chemotherapy for post-transplant lymphoproliferative disease

Transplant patients are particularly at risk of developing B post-transplant lymphoproliferative disease (PTLD) related to intensive immunosuppressive treatment to prevent graft rejection. In EBV-positive PTLDs, EBV-DNA can be found in the patients’ peripheral blood. Several methods have been descri...

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Bibliographic Details
Published in:Clinical and experimental medicine 2008-06, Vol.8 (2), p.129-132
Main Authors: Machado, Alex Sandro C., Apa, Alexandre Gustavo, Magalhães de Rezende, Lidia Maria, Amoêdo, Nívea Dias, Rumjanek, Franklin David, Bacchi, Carlos E., Klumb, Claudete Esteves
Format: Article
Language:English
Subjects:
Adolescent
Case Report
Case studies
Deoxyribonucleic acid
DNA
DNA, Viral - blood
Epstein-Barr virus
Female
Hematology
Herpesvirus 4, Human - isolation & purification
Humans
Internal Medicine
Kidney Transplantation - adverse effects
Kidneys
Lymphoproliferative Disorders - drug therapy
Lymphoproliferative Disorders - etiology
Medical research
Medicine
Medicine & Public Health
Oncology
Pediatrics
Risk factors
Transplants & implants
Viral Load
Viruses
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Summary:Transplant patients are particularly at risk of developing B post-transplant lymphoproliferative disease (PTLD) related to intensive immunosuppressive treatment to prevent graft rejection. In EBV-positive PTLDs, EBV-DNA can be found in the patients’ peripheral blood. Several methods have been described to assess peripheral blood EBV viral load. We report a case of a 13-year-old child who developed EBV-positive PTLD after renal transplantation. We assessed EBV plasma viral load by quantitative PCR and we found that the clearance of EBV-DNA correlated well with response to treatment.
ISSN:1591-8890
1591-9528
DOI:10.1007/s10238-008-0168-9