A pilot-controlled study of myeloperoxidase-specific anti-neutrophil cytoplasmic autoantibody (MPO-ANCA) in the coronary circulation

Abstract Hereby we report our observations derived from a pilot-study of 39 subjects (30 patients with coronary artery disease [CAD] and 9 non-CAD controls). In this work, we aimed to evaluate MPO-ANCA titer in the human coronary circulation for the first time; and examine its possible association w...

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Bibliographic Details
Published in:International journal of cardiology 2008-08, Vol.128 (1), p.114-116
Main Authors: Ramadan, Mahmoud M, Tachikawa, Hitoshi, Kodama, Makoto, Okawara, Akiko, Mitsuma, Wataru, Ito, Masahiro, Kashimura, Takeshi, Ikrar, Taruna, Hirono, Satoru, Okura, Yuji, Suzuki, Kazuo, Aizawa, Yoshifusa
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antibodies, Antineutrophil Cytoplasmic - blood
Biological and medical sciences
Biomarkers - blood
C-reactive protein
C-Reactive Protein - metabolism
Cardiology. Vascular system
Cardiovascular
Case-Control Studies
Coronary artery disease
Coronary Circulation
Coronary Disease - immunology
Coronary heart disease
Coronary sinus
Female
Heart
Humans
Interleukin-6
Interleukin-6 - blood
Male
Medical sciences
Middle Aged
MPO-ANCA
Peroxidase - immunology
Pilot Projects
Risk Factors
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Summary:Abstract Hereby we report our observations derived from a pilot-study of 39 subjects (30 patients with coronary artery disease [CAD] and 9 non-CAD controls). In this work, we aimed to evaluate MPO-ANCA titer in the human coronary circulation for the first time; and examine its possible association with CAD and some cytokines/inflammatory markers. We found higher mean coronary MPO-ANCA titer in CAD subjects than in non-CAD controls; beside significant positive correlations between MPO-ANCA titers and both C-reactive protein and interleukin-6 levels. Thus, we might suggest the possible involvement of MPO-ANCA in coronary atherogenesis indirectly through modulating some pro-inflammatory cytokines/markers; that a large-scale study of MPO-ANCA in CAD patients may be warranted in the future.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2007.04.119