Schizophrenia: From genes to phenes to disease

This article provides an overview of the past year’s literature on schizophrenia genetics. Quantitative genetics continues to be an important foundation in which family and twin studies have been used to evaluate potential endophenotypes. Research in molecular genetics has focused on detecting multi...

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Bibliographic Details
Published in:Current psychiatry reports 2008-08, Vol.10 (4), p.339-343
Main Authors: Allan, Charlotte L., Cardno, Alastair G., McGuffin, Peter
Format: Article
Language:English
Subjects:
Catechol O-Methyltransferase - genetics
Chromosome Aberrations
Dopamine
Gene Expression - genetics
Genetic Linkage - genetics
Genotype
Humans
Medicine
Medicine & Public Health
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Nerve Tissue Proteins - genetics
Phenotype
Psychiatry
Quantitative genetics
Schizophrenia
Schizophrenia - genetics
Twins - genetics
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Summary:This article provides an overview of the past year’s literature on schizophrenia genetics. Quantitative genetics continues to be an important foundation in which family and twin studies have been used to evaluate potential endophenotypes. Research in molecular genetics has focused on detecting multiple genes of small effect, and developments relating to key positional and functional candidate genes are reviewed. Large-scale, multicenter studies are proving to be important in this quest. Research using neuroimaging and animal modeling studies continues to link genotype with phenotype. It is increasingly apparent that some candidate genes considered important in schizophrenia are likely to be relevant to the etiology of other psychotic disorders, including bipolar disorder. This notion may challenge traditional disease classifications, not only in research but potentially in clinical practice.
ISSN:1523-3812
1535-1645
DOI:10.1007/s11920-008-0054-x