Nocardiosis in Adult-Onset Still’s Disease and Vasculitis Syndrome

Four cases of nocardiosis in patients with adult-onset Still disease and vasculitis syndrome are presented. Three patients developed lung abscesses and 1 case developed a brain abscess. All were treated with high-dose corticosteroids, and 3 were given cyclosporine when they developed nocardiosis. Al...

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Bibliographic Details
Published in:The American journal of the medical sciences 2008-07, Vol.336 (1), p.77-80
Main Authors: Tada, Yoshifumi, Mitamura, Mio, Koarada, Shuichi, Suematsu, Rie, Inoue, Hisako, Nagasawa, Kohei, Fukuoka, Mami, Ohta, Akihide
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - administration & dosage
Adult
Adult-onset Still’s disease
Aged
Bacterial diseases
Biological and medical sciences
Brain Abscess - complications
Brain Abscess - diagnostic imaging
Brain Abscess - drug therapy
Cyclosporine
Cyclosporine - administration & dosage
Female
General aspects
Human bacterial diseases
Humans
Infectious diseases
Lung Abscess - complications
Lung Abscess - diagnostic imaging
Lung Abscess - drug therapy
Male
Medical sciences
Miscellaneous
Nocardia Infections - complications
Nocardiosis
Still's Disease, Adult-Onset - complications
Tomography, X-Ray Computed
Vasculitis
Vasculitis - complications
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Summary:Four cases of nocardiosis in patients with adult-onset Still disease and vasculitis syndrome are presented. Three patients developed lung abscesses and 1 case developed a brain abscess. All were treated with high-dose corticosteroids, and 3 were given cyclosporine when they developed nocardiosis. All patients were successfully treated with antibiotics; cyclosporine was discontinued in 2 cases. These cases indicate that systemic nocardiosis can develop in patients with various rheumatologic diseases who are treated with corticosteroid and immunosuppressive drugs such as cyclosporine.
ISSN:0002-9629
1538-2990
DOI:10.1097/MAJ.0b013e318159e0b4