Influenza Virus Infection and Risk of Acute Myocardial Infarction

Increasing evidences have shown that pathogens might promote atherosclerosis and trigger acute myocardial infarction (AMI). But the conclusions from various studies on the correlation between previous influenza virus (IV) infection and AMI were inconsistent. We conducted a case-control study to asse...

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Bibliographic Details
Published in:Inflammation 2008-08, Vol.31 (4), p.266-272
Main Authors: Guan, Xiu-Ru, Li, Xin, Xin, Xiao-Min, Jiang, Li-Xin, Cui, Lan-Ying, Wang, Lan-Feng, Li, Hong-Yuan
Format: Article
Language:English
Subjects:
Adenovirus
Adult
Aged
Antibodies, Viral - blood
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Chlamydophila pneumoniae
Cytomegalovirus
Female
Herpes simplex virus 1
Herpes simplex virus 2
Humans
Immunoglobulin G - blood
Immunology
Influenza A virus - immunology
Influenza B virus - immunology
Influenza virus
Influenza, Human - complications
Influenza, Human - immunology
Influenza, Human - virology
Internal Medicine
Male
Middle Aged
Myocardial Infarction - etiology
Myocardial Infarction - immunology
Myocardial Infarction - virology
Pathology
Pharmacology/Toxicology
Rheumatology
Risk Factors
Rubella virus
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Summary:Increasing evidences have shown that pathogens might promote atherosclerosis and trigger acute myocardial infarction (AMI). But the conclusions from various studies on the correlation between previous influenza virus (IV) infection and AMI were inconsistent. We conducted a case-control study to assess the association of previous IV infection and AMI. Questionnaire survey was conducted to collect information about demographic characteristics and heart disease risk factors. Fasting blood sample was obtained to measure IgG antibodies to influenza virus A(IV-A), influenza virus B(IV-B), cytomegalovirus (CMV), herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2), adenovirus (ADV), rubella virus (RV) and Chlamydia pneumoniae (CP) and measure the level of some biochemistry markers. Compared to controls, cases were more likely to have positive IgG antibodies to IV-A and IV-B ( IV-A: OR, 3.3; 95%CI, 1.5 to 7.4; IV-B: OR, 17.2; 95%CI, 7.7 to 38.0 ) . After adjustment for potential confounding variables, the risk of AMI was still associated with the presence of IgG antibodies to IV-A ( adjusted OR, 7.5; 95%CI, 1.3 to 43.0) and IV-B (adjusted OR, 27.3; 95%CI, 6.6 to 113.8 ) . The study supported the hypothesis that previous IV infection took part in the development of atherosclerosis and trigger the occurrence of AMI.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-008-9074-2