An Efficient Copper−Aluminum Hydrotalcite Catalyst for Asymmetric Hydrosilylation of Ketones at Room Temperature

A catalyst system consisting of a copper−aluminum hydrotalcite−chiral diphosphine ligand effects asymmetric hydrosilylation of several ketones, using polymethylhydrosiloxane (PMHS) as the stoichiometric reducing agent at room temperature, with moderate-to-excellent enantioselectivities. The catalyst...

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Bibliographic Details
Published in:Organic letters 2008-07, Vol.10 (14), p.2979-2982
Main Authors: Kantam, M. Lakshmi, Laha, Soumi, Yadav, Jagjit, Likhar, Pravin R, Sreedhar, Bojja, Jha, Shailendra, Bhargava, Suresh, Udayakiran, M, Jagadeesh, B
Format: Article
Language:English
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Summary:A catalyst system consisting of a copper−aluminum hydrotalcite−chiral diphosphine ligand effects asymmetric hydrosilylation of several ketones, using polymethylhydrosiloxane (PMHS) as the stoichiometric reducing agent at room temperature, with moderate-to-excellent enantioselectivities. The catalyst is recovered by simple centrifugation, and the efficiency of the catalyst remains almost unaltered even after several cycles.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol800616p