Asymmetric multifunctional organocatalytic Michael addition of nitroalkanes to alpha,beta-unsaturated ketones

Cinchona alkaloid derived primary amine thioureas organocatalyzed Michael addition of nitroalkanes to enones in good yield and up to 98% ee and offered a new way to construct quaternary stereocenters from enones and nitroalkanes.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2008-01 (28), p.3302-3304
Main Authors: Li, Pengfei, Wang, Yongcan, Liang, Xinmiao, Ye, Jinxing
Format: Article
Language:English
Subjects:
Alkanes - chemistry
Catalysis
Cinchona Alkaloids - chemistry
Ketones - chemistry
Nitro Compounds - chemistry
Stereoisomerism
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Description
Summary:Cinchona alkaloid derived primary amine thioureas organocatalyzed Michael addition of nitroalkanes to enones in good yield and up to 98% ee and offered a new way to construct quaternary stereocenters from enones and nitroalkanes.
ISSN:1359-7345
1364-548X
DOI:10.1039/b804540b