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Prognostic Significance of Fascin Expression in Advanced Poorly Differentiated Serous Ovarian Cancer
Background: High expression of the actin-bundling protein fascin correlates well with histological grade and clinical stage of ovarian carcinoma. This study addresses fascin expression in advanced poorly differentiated serous ovarian cancer with respect to progression free interval (PFI) and overall...
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| Published in: | Anticancer research 2008-05, Vol.28 (3B), p.1905-1910 |
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| container_end_page | 1910 |
| container_issue | 3B |
| container_start_page | 1905 |
| container_title | Anticancer research |
| container_volume | 28 |
| creator | DAPONTE, Alexandros KOSTOPOULOU, Eva MINAS, Marco KOUKOULIS, George MESSINIS, Ioannis E |
| description | Background: High expression of the actin-bundling protein fascin correlates well with histological grade and clinical stage
of ovarian carcinoma. This study addresses fascin expression in advanced poorly differentiated serous ovarian cancer with
respect to progression free interval (PFI) and overall survival. Patients and Methods: Fascin and Ki-67 expression were analysed
in paraffin blocks tissue sections of 56 stage III, poorly differentiated (G3) serous adenocarcinoma patients by immunohistochemistry.
Fascin expression was tested for correlation with PFI and overall survival. Results: Fascin expression inversely correlated
with Ki-67 expression (p=0.016). Strong fascin immunoreactivity was associated with poor prognosis; patients with low fascin
expression had a median survival of 36.5 months versus 32 months for high fascin expression (p=0.041), and the median PFl
was 24 versus 17.5 months (p=0.034). Conclusion: Fascin expression is an independent prognostic factor for survival of advanced
ovarian serous carcinoma, and may represent a novel therapeutic target for patients with aggressive forms of ovarian cancer. |
| format | article |
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of ovarian carcinoma. This study addresses fascin expression in advanced poorly differentiated serous ovarian cancer with
respect to progression free interval (PFI) and overall survival. Patients and Methods: Fascin and Ki-67 expression were analysed
in paraffin blocks tissue sections of 56 stage III, poorly differentiated (G3) serous adenocarcinoma patients by immunohistochemistry.
Fascin expression was tested for correlation with PFI and overall survival. Results: Fascin expression inversely correlated
with Ki-67 expression (p=0.016). Strong fascin immunoreactivity was associated with poor prognosis; patients with low fascin
expression had a median survival of 36.5 months versus 32 months for high fascin expression (p=0.041), and the median PFl
was 24 versus 17.5 months (p=0.034). Conclusion: Fascin expression is an independent prognostic factor for survival of advanced
ovarian serous carcinoma, and may represent a novel therapeutic target for patients with aggressive forms of ovarian cancer.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 18630479</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Biological and medical sciences ; Carrier Proteins - biosynthesis ; Cell Growth Processes - physiology ; Cystadenocarcinoma, Serous - metabolism ; Cystadenocarcinoma, Serous - pathology ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Ki-67 Antigen - biosynthesis ; Medical sciences ; Microfilament Proteins - biosynthesis ; Middle Aged ; Neoplasm Staging ; Ovarian Neoplasms - metabolism ; Ovarian Neoplasms - pathology ; Tumors</subject><ispartof>Anticancer research, 2008-05, Vol.28 (3B), p.1905-1910</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20444696$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18630479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DAPONTE, Alexandros</creatorcontrib><creatorcontrib>KOSTOPOULOU, Eva</creatorcontrib><creatorcontrib>MINAS, Marco</creatorcontrib><creatorcontrib>KOUKOULIS, George</creatorcontrib><creatorcontrib>MESSINIS, Ioannis E</creatorcontrib><title>Prognostic Significance of Fascin Expression in Advanced Poorly Differentiated Serous Ovarian Cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: High expression of the actin-bundling protein fascin correlates well with histological grade and clinical stage
of ovarian carcinoma. This study addresses fascin expression in advanced poorly differentiated serous ovarian cancer with
respect to progression free interval (PFI) and overall survival. Patients and Methods: Fascin and Ki-67 expression were analysed
in paraffin blocks tissue sections of 56 stage III, poorly differentiated (G3) serous adenocarcinoma patients by immunohistochemistry.
Fascin expression was tested for correlation with PFI and overall survival. Results: Fascin expression inversely correlated
with Ki-67 expression (p=0.016). Strong fascin immunoreactivity was associated with poor prognosis; patients with low fascin
expression had a median survival of 36.5 months versus 32 months for high fascin expression (p=0.041), and the median PFl
was 24 versus 17.5 months (p=0.034). Conclusion: Fascin expression is an independent prognostic factor for survival of advanced
ovarian serous carcinoma, and may represent a novel therapeutic target for patients with aggressive forms of ovarian cancer.</description><subject>Biological and medical sciences</subject><subject>Carrier Proteins - biosynthesis</subject><subject>Cell Growth Processes - physiology</subject><subject>Cystadenocarcinoma, Serous - metabolism</subject><subject>Cystadenocarcinoma, Serous - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-67 Antigen - biosynthesis</subject><subject>Medical sciences</subject><subject>Microfilament Proteins - biosynthesis</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNpFkE9PAjEQxTdGI4h-BdOL3jaZ3Xa7u0dEUBMSSNBzM_QP1CxbbBeUb2-JqKfJzPzyZt47S_pZWWdpWVA4T_qQF5CWAEUvuQrhHYDzuqKXSS-rOAVW1v1Ezb1btS50VpKFXbXWWImt1MQZMsEgbUvGX1uvQ7CuJbEbqv1xr8jcOd8cyKM1Rnvddha7OF1o73aBzPboLbZkdGT9dXJhsAn65lQHydtk_Dp6Tqezp5fRcJqu8xK6lAGCgoJW2mSqYAXmFDUURnIOlOVSSWagQqoBczRUmdgqzQFlsayWGdJBcv-ju_XuY6dDJzY2SN002Or4leA1zVjGaQRvT-BuudFKbL3doD-I31wicHcCYgbYGB992PDH5cAY4zX_v7i2q_Wn9VqEDTZNlKUCfV4J-iCyOnr6BrsHex8</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>DAPONTE, Alexandros</creator><creator>KOSTOPOULOU, Eva</creator><creator>MINAS, Marco</creator><creator>KOUKOULIS, George</creator><creator>MESSINIS, Ioannis E</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20080501</creationdate><title>Prognostic Significance of Fascin Expression in Advanced Poorly Differentiated Serous Ovarian Cancer</title><author>DAPONTE, Alexandros ; KOSTOPOULOU, Eva ; MINAS, Marco ; KOUKOULIS, George ; MESSINIS, Ioannis E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h270t-40a0d0538ef1d545a23ae05fc660342cdc4f08a3e0a2af3df4f0de60ac5b8b1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Carrier Proteins - biosynthesis</topic><topic>Cell Growth Processes - physiology</topic><topic>Cystadenocarcinoma, Serous - metabolism</topic><topic>Cystadenocarcinoma, Serous - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ki-67 Antigen - biosynthesis</topic><topic>Medical sciences</topic><topic>Microfilament Proteins - biosynthesis</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DAPONTE, Alexandros</creatorcontrib><creatorcontrib>KOSTOPOULOU, Eva</creatorcontrib><creatorcontrib>MINAS, Marco</creatorcontrib><creatorcontrib>KOUKOULIS, George</creatorcontrib><creatorcontrib>MESSINIS, Ioannis E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DAPONTE, Alexandros</au><au>KOSTOPOULOU, Eva</au><au>MINAS, Marco</au><au>KOUKOULIS, George</au><au>MESSINIS, Ioannis E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Significance of Fascin Expression in Advanced Poorly Differentiated Serous Ovarian Cancer</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>28</volume><issue>3B</issue><spage>1905</spage><epage>1910</epage><pages>1905-1910</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: High expression of the actin-bundling protein fascin correlates well with histological grade and clinical stage
of ovarian carcinoma. This study addresses fascin expression in advanced poorly differentiated serous ovarian cancer with
respect to progression free interval (PFI) and overall survival. Patients and Methods: Fascin and Ki-67 expression were analysed
in paraffin blocks tissue sections of 56 stage III, poorly differentiated (G3) serous adenocarcinoma patients by immunohistochemistry.
Fascin expression was tested for correlation with PFI and overall survival. Results: Fascin expression inversely correlated
with Ki-67 expression (p=0.016). Strong fascin immunoreactivity was associated with poor prognosis; patients with low fascin
expression had a median survival of 36.5 months versus 32 months for high fascin expression (p=0.041), and the median PFl
was 24 versus 17.5 months (p=0.034). Conclusion: Fascin expression is an independent prognostic factor for survival of advanced
ovarian serous carcinoma, and may represent a novel therapeutic target for patients with aggressive forms of ovarian cancer.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>18630479</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Anticancer research, 2008-05, Vol.28 (3B), p.1905-1910 |
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| language | eng |
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| subjects | Biological and medical sciences Carrier Proteins - biosynthesis Cell Growth Processes - physiology Cystadenocarcinoma, Serous - metabolism Cystadenocarcinoma, Serous - pathology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Ki-67 Antigen - biosynthesis Medical sciences Microfilament Proteins - biosynthesis Middle Aged Neoplasm Staging Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Tumors |
| title | Prognostic Significance of Fascin Expression in Advanced Poorly Differentiated Serous Ovarian Cancer |
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