Mitochondrial AIF protein involved in skeletal muscle regeneration

The mitochondrial flavoprotein apoptosis‐inducing factor (AIF) has proved to be either the main mediator of apoptosis or an anti‐apoptotic factor via its putative oxidoreductase and peroxide scavenging activities. We report here that 100 µM hydrogen peroxide (H2O2) induced the proliferation of C2C12...

Full description

Saved in:
Bibliographic Details
Published in:Cell biochemistry and function 2008-07, Vol.26 (5), p.598-602
Main Authors: Qiu, Xiao-zhong, Yu, Lei, Lai, Gui-hua, Wang, Le-yu, Chen, Bing, Ouyang, Jun
Format: Article
Language:English
Subjects:
AIF
Animals
Apoptosis Inducing Factor - biosynthesis
Apoptosis Inducing Factor - genetics
Apoptosis Inducing Factor - physiology
C2C12 cell lines
Cell Line
Hydrogen Peroxide - metabolism
Male
Mice
Mitochondrial Proteins - biosynthesis
Mitochondrial Proteins - genetics
Mitochondrial Proteins - physiology
Muscle Development - physiology
Muscle, Skeletal - physiology
Rats
Rats, Sprague-Dawley
regeneration
Regeneration - physiology
skeletal muscle
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The mitochondrial flavoprotein apoptosis‐inducing factor (AIF) has proved to be either the main mediator of apoptosis or an anti‐apoptotic factor via its putative oxidoreductase and peroxide scavenging activities. We report here that 100 µM hydrogen peroxide (H2O2) induced the proliferation of C2C12 myoblasts and over‐expression of AIF simultaneously in vitro. Immunofluorescence showed that the over‐expression of AIF was located in the cytoplasm. The immunopositive AIF was detected in nuclei 27 days after denervation of skeletal muscle, but in the cytoplasm it was detected 27 days after fiber‐damaged skeletal muscle. AIF may be a factor involved in skeletal muscle regeneration. Copyright © 2008 John Wiley & Sons, Ltd.
ISSN:0263-6484
1099-0844
DOI:10.1002/cbf.1483