Better Assessment of Nodal Metastases by PET/CT Fusion Compared to Side-by-Side PET/CT in Oesophageal Cancer

Background: Recently, positron emission tomography/computed tomography (PET/CT) has been introduced in the staging of oesophageal cancer. The impact of PET/CT fusion in comparison with side-by-side PET/CT in these tumours, was analyzed. Patients and Methods: In 61 patients, 18-F-fluorodeoxyglucose (...

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Bibliographic Details
Published in:Anticancer research 2008-05, Vol.28 (3B), p.1867-1873
Main Authors: SCHREURS, Liesbeth M, PULTRUM, Bareld B, KOOPMANS, Klaas P, VERHOEF, Christian C, JAGER, Pieter L, VAN DAM, Gooitzen M, GROEN, Henk, VAN DER JAGT, Erik J, PLUKKER, John Th. M
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Esophageal Neoplasms - diagnostic imaging
Esophageal Neoplasms - pathology
Esophagus
Female
Fluorine Radioisotopes
Fluorodeoxyglucose F18
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Lymph Nodes - diagnostic imaging
Lymph Nodes - pathology
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Neoplasm Staging
Positron-Emission Tomography - methods
Radiopharmaceuticals
Retrospective Studies
Tomography, X-Ray Computed - methods
Tumors
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Summary:Background: Recently, positron emission tomography/computed tomography (PET/CT) has been introduced in the staging of oesophageal cancer. The impact of PET/CT fusion in comparison with side-by-side PET/CT in these tumours, was analyzed. Patients and Methods: In 61 patients, 18-F-fluorodeoxyglucose (FDG)-PET and multidetector (md)-CT were performed within a two week interval. Software-fusion of md-CT and FDG-PET was correlated with side-by-side FDG-PET/CT reading by two independent investigators. The gold standard was the pathological outcome or clinical evidence of progression during the first year of follow-up. Results: In 18 patients (18/61; 30%), nodal staging improved with software-fusion. The number of nodal metastases increased in five patients and decreased in four patients, leading to up-staging in one patient (2%) and down-staging in three patients (5%). In nine cases (15%), certainty and localization of metastases improved. However, the number of distant metastases did not change and software-fusion did not have an influence on resectability. Conclusion: PET/CT fusion substantially improves detection and localization of nodal metastases and may have an impact on locoregional treatment options.
ISSN:0250-7005
1791-7530