Low-grade urinary albumin excretion in normotensive/non-diabetic obstructive sleep apnea patients

• Published in: Sleep & breathing 2008-08, Vol.12 (3), p.217-222
• Main Authors: Ursavas, Ahmet, Karadag, Mehmet, Gullulu, Mustafa, Demirdogen, Ezgi, Coskun, Funda, Onart, Selcuk, Gozu, R. Oktay
• Format: Article
• Language: English
• Subjects: Albumins - metabolism; Biological and medical sciences; Blood Pressure - physiology; Body Mass Index; Cardiovascular disease; Cross-Sectional Studies; Dentistry; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes; Drug therapy; Female; Fundamental and applied biological sciences. Psychology; Humans; Internal Medicine; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Nervous system (semeiology, syndromes); Neurology; Original Article; Otorhinolaryngology; Pediatrics; Pneumology/Respiratory System; Sleep apnea; Sleep Apnea, Obstructive - epidemiology; Sleep Apnea, Obstructive - urine; Sleep. Vigilance; Surveys and Questionnaires; Vertebrates: nervous system and sense organs
• ISSN: 1520-9512; 1522-1709
• DOI: 10.1007/s11325-008-0169-7

Previous studies have indicated that high levels of urinary albumin excretion (UAE) are associated with an increased incidence of cardiovascular morbidity and mortality. This study examined the association between UAE and obstructive sleep apnea syndrome (OSAS). The study included 35 newly diagnosed OSAS patients and 11 nonapneic controls. Subjects with diabetes mellitus, hypertension, a history of renal failure, cardiac failure, coronary heart disease, collagen tissue disease, high serum creatinine, and urinary infection, and who use angiotensin-converting enzyme inhibitors and were women were excluded from the study. A single void morning urine sample at the baseline examination was used to measure UAE. There were no significant differences in the age, body mass index (BMI), and smoking habits of the OSAS patients and controls. UAE of the OSAS group was significantly higher than that of the control group (23.3 ± 6.1 μg/min vs. 6.5 ± 2.1 μg/min, respectively; P  = 0.002). UAE was positively correlated to length of time spent at an oxygen saturation of