A mammary gland adenomyoepithelioma in a C57BL/6 mouse

Mammary gland adenomyoepitheliomas are benign complex mammary gland tumors composed of neoplastic cells of epithelial and myoepithelial origins, described in many species (humans, dogs, cats, rats) and rarely in mice. We report here an adenomyoepithelioma in a C57BL/6 female mouse. Histologically, t...

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Bibliographic Details
Published in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2008-08, Vol.60 (4), p.307-311
Main Authors: Bauchet, Anne-Laure, Elies, Laëtitia, Maliver, Pierre, Fouque, Marie-Claude, Balme, Emmanuelle, Château-Joubert, Sophie, Schorsch, Frédéric, Fontaine, Jean-Jacques
Format: Article
Language:English
Subjects:
Adenomyoepithelioma
Animals
Biological and medical sciences
C57BL/6
Complex mammary gland tumor
Female
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Mammary gland
Mammary Neoplasms, Animal - metabolism
Mammary Neoplasms, Animal - pathology
Medical sciences
Mice
Mice, Inbred C57BL
Mouse
Myoepithelioma - metabolism
Myoepithelioma - pathology
Myoepithelioma - veterinary
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
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Summary:Mammary gland adenomyoepitheliomas are benign complex mammary gland tumors composed of neoplastic cells of epithelial and myoepithelial origins, described in many species (humans, dogs, cats, rats) and rarely in mice. We report here an adenomyoepithelioma in a C57BL/6 female mouse. Histologically, tubes and cords formed by neoplastic epithelial cells were separated by bundles of neoplastic myoepithelial cells in a clear and partially mucinous matrix. The tumor displayed characteristics of a benign neoplastic proliferation with a compressive growth pattern, and moderate cellular pleomorphism and mitotic index. At immunohistochemistry, the epithelial cells were strongly cytokeratin positive; the myoepithelial cells were weakly cytokeratin positive and strongly smooth muscle actin positive. This is to our knowledge, the first report of a mammary gland adenomyoepithelioma in a C57BL/6 mouse.
ISSN:0940-2993
1618-1433
DOI:10.1016/j.etp.2008.02.008