Adaptive Foxp3 + Regulatory T Cell-Dependent and -Independent Control of Allergic Inflammation

Adaptive Foxp3 + regulatory T (Treg) cells develop during induction of mucosal tolerance and after immunization. Large numbers of Foxp3 + T cells have been found in inflamed tissues. We investigated the role of adaptive Foxp3 + Treg cells in mucosal tolerance and in chronic allergic lung inflammatio...

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Published in:Immunity (Cambridge, Mass.) Mass.), 2008-07, Vol.29 (1), p.114-126
Main Authors: Curotto de Lafaille, Maria A., Kutchukhidze, Nino, Shen, Shiqian, Ding, Yi, Yee, Herman, Lafaille, Juan J.
Format: Article
Language:English
Subjects:
Allergies
Animals
Asthma
Cell Differentiation - immunology
CELLIMMUNOL
Cytokines
Flow Cytometry
Forkhead Transcription Factors - genetics
Forkhead Transcription Factors - immunology
Immune Tolerance
Immunity, Mucosal
Inflammation - immunology
Intestinal Mucosa - immunology
Lymphocytes
Mice
Mice, Mutant Strains
Mutation
Ovalbumin - immunology
Pathology
Polymerase Chain Reaction
Respiratory Hypersensitivity - immunology
Respiratory Mucosa - immunology
Rodents
T cell receptors
T-Lymphocytes, Regulatory - cytology
T-Lymphocytes, Regulatory - immunology
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Summary:Adaptive Foxp3 + regulatory T (Treg) cells develop during induction of mucosal tolerance and after immunization. Large numbers of Foxp3 + T cells have been found in inflamed tissues. We investigated the role of adaptive Foxp3 + Treg cells in mucosal tolerance and in chronic allergic lung inflammation. We used two strains of mice that are devoid of naturally occurring Treg cells; one is capable of generating adaptive Foxp3 + Treg cells upon exposure to antigen, whereas the other is deficient in both naturally occurring and adaptive Foxp3 + Treg cells. We found that adaptive Foxp3 + Treg cells were essential for establishing mucosal tolerance and for suppressing IL-4 production and lymphoid neogenesis in chronic inflammation, whereas IL-5 production and eosinophilia could be controlled by Foxp3-independent, IFN-γ-dependent mechanisms. Thus, whereas adaptive Foxp3 + Treg cells regulate sensitization to allergens and the severity of chronic inflammation, IFN-γ-producing cells can play a beneficial role in inflammatory conditions involving eosinophils.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2008.05.010