Effects of herring roe on plasma lipid, glucose,insulin and adiponectin levels, and hepatic lipid contents in mice

• Published in: Journal of Nutritional Science and Vitaminology 2008, Vol.54(3), pp.230-236
• Main Authors: Higuchi, T.(Kagawa Nutrition Univ., Sakado, Saitama (Japan)), Shirai, N, Suzuki, H
• Format: Article
• Language: English
• Subjects: ACIDE GRAS INSATURE; ACIDOS GRASOS INSATURADOS; Adiponectin - blood; Adipose Tissue - drug effects; Adipose Tissue - physiology; Animal Nutritional Physiological Phenomena - drug effects; Animal Nutritional Physiological Phenomena - physiology; Animals; ARENQUE; Biological and medical sciences; Blood Glucose - drug effects; Body Weight - drug effects; Body Weight - physiology; Diet - methods; Eating - drug effects; Eating - physiology; Eggs - analysis; Feeding. Feeding behavior; Fish Proteins - administration & dosage; Fish Proteins - pharmacology; Fishes; Fundamental and applied biological sciences. Psychology; GLUCOSA; GLUCOSE; HARENG; herring roe; HERRINGS; HUEVAS; INSULIN; Insulin - blood; INSULINA; INSULINE; Lipid Metabolism - drug effects; Lipid Metabolism - physiology; LIPIDE; LIPIDOS; LIPIDS; Lipids - blood; Liver - drug effects; Liver - metabolism; Male; MICE; Mice, Inbred ICR; n-3 polyunsaturated fatty acid; OEUFS DE POISSON; Organ Size - drug effects; Organ Size - physiology; plasma glucose; plasma lipids; RATON; ROES; SOURIS; UNSATURATED FATTY ACIDS; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0301-4800; 1881-7742
• DOI: 10.3177/jnsv.54.230

We previously reported that lipids extracted from salted herring roe product (Kazunoko), which contains large amounts of cholesterol, phosphatidylcholine and n-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3), decreased plasma lipid and glucose concentrations in mice. The aim of this study was to evaluate the effects of Kazunoko containing large amounts of protein on lipid and glucose metabolism in mice. Male Crlj:CD-1 (ICR) mice were fed three experimental diets containing lyophilized Kazunoko for 12 wk. The experimental diets were as follows: without Kazunoko (control diet); 1% Kazunoko (1% Kazunoko diet); and 4% Kazunoko (4% Kazunoko diet). Plasma total cholesterol, phospholipid and glucose concentrations tended to be lower in the 1% and 4% Kazunoko diet groups than in the control diet group. There were significant differences in plasma glucose concentration between the control and 4% Kazunoko diet groups (p0.05). Plasma adiponectin concentrations in mice fed the 4% Kazunoko diet were also significantly higher than in those fed the control diet (p0.05), but there were no marked differences in plasma insulin concentration among the three dietary groups. Hepatic total cholesterol and phospholipid contents tended to be lower in the 4% Kazunoko diet group than in control diet group. Plasma and hepatic n-3/n-6 ratios in the 1% Kazunoko diet and 4% Kazunoko diet groups were significantly higher when compared with those of the control diet group (p0.005 and p0.0005, respectively). These results suggest that ingestion of Kazunoko influences lipid and glucose metabolism in mice fed the Kazunoko diets, as compared with animals fed the control diet.