Methylsulfomycin I, a New Cyclic Peptide Antibiotic from a Streptomyces sp. HIL Y-9420704

Methylsulfomycin I (1) is a new cyclic peptide antibiotic isolated from the fermentation broth of a Streptomyces sp. HIL Y-9420704. Its structure was elucidated by NMR and GC−MS. The in vitro activity (MIC) against a wide range of Gram-positive bacteria, including methicillin-resistant Staphylococcu...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-11, Vol.62 (11), p.1562-1564
Main Authors: Vijaya Kumar, E. K. S, Kenia, J, Mukhopadhyay, Triptikumar, Nadkarni, S. R
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
antibacterial properties
antibiotics
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Bacteria - drug effects
Biological and medical sciences
chemical composition
chemical structure
Chromatography, High Pressure Liquid
cyclic peptides
drug resistance
Fermentation
Fundamental and applied biological sciences. Psychology
Gram-positive bacteria
methicillin
Mice
Microbial Sensitivity Tests
Microbiology
Molecular Conformation
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
soil bacteria
Solvents
spectral analysis
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Staphylococcus aureus
Streptomyces
Streptomyces - metabolism
teicoplanin
vancomycin
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Summary:Methylsulfomycin I (1) is a new cyclic peptide antibiotic isolated from the fermentation broth of a Streptomyces sp. HIL Y-9420704. Its structure was elucidated by NMR and GC−MS. The in vitro activity (MIC) against a wide range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-, and teicoplanin-resistant strains, is described.
ISSN:0163-3864
1520-6025
DOI:10.1021/np990088y