Complete cervical or thoracic spinal cord transections delay gastric emptying and gastrointestinal transit of liquid in awake rats

Study Design:  To determine the changes on gastric emptying and gastrointestinal transit of liquid throughout the first week after spinal cord transection (SCT) in rats. Methods:  Male Wistar rats ( n =121) were fasted for 16 h and a complete SCT or laminectomy was performed between C 7 and T 1 (cer...

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Published in:Spinal cord 1999-11, Vol.37 (11), p.793-799
Main Authors: Gondim, FAA, Alencar, HMP, Rodrigues, CL, da Graça, JRV, dos Santos, AA, Rola, FH
Format: Article
Language:English
Subjects:
Anatomy
Animals
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cervical Vertebrae
Gastric Emptying - physiology
Gastrointestinal Transit - physiology
Human Physiology
Injuries of the nervous system and the skull. Diseases due to physical agents
Male
Medical sciences
Neurochemistry
Neuropsychology
Neurosciences
original-article
Rats
Rats, Wistar
Spinal Cord Injuries - physiopathology
Thoracic Vertebrae
Traumas. Diseases due to physical agents
Tropical medicine
Water - physiology
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Summary:Study Design:  To determine the changes on gastric emptying and gastrointestinal transit of liquid throughout the first week after spinal cord transection (SCT) in rats. Methods:  Male Wistar rats ( n =121) were fasted for 16 h and a complete SCT or laminectomy was performed between C 7 and T 1 (cervical group) or between T 4 and T 5 (thoracic group). Dye recovery in the stomach, proximal, mid and distal small intestine was determined 30 min, 6 h, 1, 3 or 7 days after surgery. The test meal (1.5 ml of a phenol red solution, 0.5 mg/ml in 5% glucose) was intragastrically administered and the animals sacrificed by cervical dislocation 10 min later. Results:  Cervical SCT increased dye recovery in the stomach ( P
ISSN:1362-4393
1476-5624
DOI:10.1038/sj.sc.3100923