Production of 6-Deoxy-13-cyclopropyl-Erythromycin B by Saccharopolyspora erythraea NRRL 18643

Cyclopropane carboxylic acid was fed to Saccharopolyspora erythraea NRRL 18643 (6-deoxyerythromycin producer), resulting in the production of 6-deoxy-13-cyclopropyl-erythromycin B. These studies provide further evidence that deoxyerythronolide B synthase has a relaxed specificity for the starter uni...

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Bibliographic Details
Published in:Journal of antibiotics 1999/08/25, Vol.52(8), pp.742-747
Main Authors: BROWN, MARIA S., DIRLAM, JOHN P., MCARTHUR, HAMISH A. I., MCCORMICK, ELLEN L., MORSE, BROOK K., MURPHY, PAUL A., O'CONNELL, THOMAS N., PACEY, MIKE, RESCEK, DIANNE M., RUDDOCK, JOHN, WAX, RICHARD G.
Format: Article
Language:English
Subjects:
6-Deoxy-13-cyclopropyl-erythromycin B
6-Deoxyerythromycin
6-Deoxyerythronolide B synthase
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Applied microbiology
Biological and medical sciences
cyclopropane carboxylic acid
Cyclopropanes - metabolism
Erythromycin - analogs & derivatives
Erythromycin - chemistry
Erythromycin - metabolism
Erythromycin - pharmacology
Fundamental and applied biological sciences. Psychology
Macrolides
Magnetic Resonance Spectroscopy
Medical sciences
Microbial Sensitivity Tests
Microbiology
Molecular Structure
Pharmacology. Drug treatments
Saccharopolyspora - genetics
Saccharopolyspora - metabolism
Saccharopolyspora erythraea
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Summary:Cyclopropane carboxylic acid was fed to Saccharopolyspora erythraea NRRL 18643 (6-deoxyerythromycin producer), resulting in the production of 6-deoxy-13-cyclopropyl-erythromycin B. These studies provide further evidence that deoxyerythronolide B synthase has a relaxed specificity for the starter unit.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.52.742