Covalent inhibitors of glycosidases and their applications in biochemistry and biology

Glycoside hydrolases are important enzymes in a number of essential biological processes. Irreversible inhibitors of this class of enzyme have attracted interest as probes of both structure and function. In this review we discuss some of the compounds used to covalently modify glycosidases, their us...

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Bibliographic Details
Published in:Glycobiology (Oxford) 2008-08, Vol.18 (8), p.570-586
Main Authors: Rempel, Brian P, Withers, Stephen G
Format: Article
Language:English
Subjects:
affinity label
Animals
Biochemistry
Biology
Enzyme Inhibitors - pharmacology
Fluorine Compounds - chemistry
Fluorine Compounds - pharmacology
glycoside hydrolase
Glycoside Hydrolases - antagonists & inhibitors
Glycoside Hydrolases - classification
Glycoside Hydrolases - metabolism
Humans
mechanism-based inactivator
Protein Binding
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Summary:Glycoside hydrolases are important enzymes in a number of essential biological processes. Irreversible inhibitors of this class of enzyme have attracted interest as probes of both structure and function. In this review we discuss some of the compounds used to covalently modify glycosidases, their use in residue identification, structural and mechanistic investigations, and finally their applications, both in vitro and in vivo, to complex biological systems.
ISSN:0959-6658
1460-2423
DOI:10.1093/glycob/cwn041