Unusual granulomatous variant of scleromyxedema

Scleromyxedema is notable for significant morbidity and mortality. A generalized eruption of waxy papules in the absence of thyroid disease with histologic findings of mucin deposition, increased fibroblast proliferation, and fibrosis are the characteristic features of scleromyxedema. We report a ca...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2008-08, Vol.59 (2), p.346-349
Main Authors: Stetsenko, Galina Y., MD, MHA, Vary, Jay C., MD, PhD, Olerud, John E., MD, Argenyi, Zsolt B., MD
Format: Article
Language:English
Subjects:
Biological and medical sciences
Dermatology
Diagnosis, Differential
Granuloma Annulare - complications
Granuloma Annulare - diagnosis
Granuloma Annulare - pathology
Humans
Male
Medical sciences
Middle Aged
Pruritus - etiology
Scleromyxedema - complications
Scleromyxedema - diagnosis
Scleromyxedema - pathology
Skin involvement in other diseases. Miscellaneous. General aspects
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Summary:Scleromyxedema is notable for significant morbidity and mortality. A generalized eruption of waxy papules in the absence of thyroid disease with histologic findings of mucin deposition, increased fibroblast proliferation, and fibrosis are the characteristic features of scleromyxedema. We report a case of scleromyxedema that, on histology, was associated with interstitial granuloma annulare-like features. Based on our literature review, this is a rare presentation of this disease. Familiarity with the histologic aspects of scleromyxedema, as described in this report, can help to improve the accuracy of this diagnosis, particularly in atypical presentations.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2008.04.017