Serial evoked potential studies and MRI imaging in chronic progressive multiple sclerosis

Measurements of serial evoked potential latencies and plaque burden on MRI scans are often obtained during clinical studies of multiple sclerosis patients to provide additional information to the disability-based primary endpoints. The ideal laboratory-based marker of progression would be expected t...

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Bibliographic Details
Published in:Journal of the neurological sciences 1999-12, Vol.171 (2), p.79-83
Main Authors: Sater, Richard A, Rostami, A.M, Galetta, Steven, Farber, Roger E, Bird, Shawn J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brainstem auditory evoked potentials
Chronic progressive multiple sclerosis
Disability Evaluation
Electrodiagnosis. Electric activity recording
Evoked Potentials, Auditory, Brain Stem - physiology
Evoked Potentials, Visual - physiology
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
MRI
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Multiple Sclerosis, Chronic Progressive - pathology
Multiple Sclerosis, Chronic Progressive - physiopathology
Nervous system
Neurology
Visual evoked potential
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Summary:Measurements of serial evoked potential latencies and plaque burden on MRI scans are often obtained during clinical studies of multiple sclerosis patients to provide additional information to the disability-based primary endpoints. The ideal laboratory-based marker of progression would be expected to significantly change over the time period of study. Serial visual (VEP) and brainstem auditory evoked potentials (BAEP) and MRI scans of 11 chronic progressive MS patients were obtained over a 1.5 year period in a clinical study. Over this period, there was no significant change in disability as measured by the Kurtzke EDSS, Ambulation Index or Neurological Rating Score. The VEP P100 significantly progressed over the period of study. However, the MRI T 2 plaque burden and BAEP I–V intrapeak latency did not significantly progress over the 1.5 years. We conclude that, in chronic progressive MS, serial visual evoked potential tests may complement standard disability-based endpoints to assess disease progression.
ISSN:0022-510X
1878-5883
DOI:10.1016/S0022-510X(99)00255-5