Association of IL-10 receptor 2 ( IL10RB) SNP with systemic sclerosis

• Published in: Biochemical and biophysical research communications 2008-08, Vol.373 (3), p.403-407
• Main Authors: Hikami, Koki, Ehara, Yukikazu, Hasegawa, Minoru, Fujimoto, Manabu, Matsushita, Masaki, Oka, Takanori, Takehara, Kazuhiko, Sato, Shinichi, Tokunaga, Katsushi, Tsuchiya, Naoyuki
• Format: Article
• Language: English
• Subjects: Adult; Female; Genetic Predisposition to Disease; Genetics; Humans; IL-10 receptor; Interleukin-10 - blood; Interleukin-10 Receptor beta Subunit - genetics; Linkage Disequilibrium; Male; Middle Aged; Polymorphism; Polymorphism, Single Nucleotide; Scleroderma, Diffuse - genetics; Systemic sclerosis
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1016/j.bbrc.2008.06.054

Interleukin-10 (IL-10) signaling has been suggested to play a role in systemic sclerosis (SSc). IL10RB codes for IL-10 receptor 2 (IL-10R2), a component shared in receptor complexes for IL-10, IL-22, IL-26 and interferon (IFN)-λ. In this study, we examined association of IL10RB polymorphism with susceptibility to SSc. Genotype A/A at rs2834167 (47K/K) was significantly increased in diffuse cutaneous SSc (dcSSc) (41.3% in dcSSc, 20.9% in controls, P = 0.0018, odds ratio = 2.67). A SNP in the 5′ flanking region of IL10RB, rs999788, also showed association with dcSSc; however, this association was shown to be secondarily caused by linkage disequilibrium with rs2834167. Significant association was not observed in limited cutaneous SSc (lcSSc). Presence of anti-topoisomerase I antibody was also associated with rs2834167A/A genotype ( P = 0.0019). Serum IL-10 level was significantly associated with the number of rs2834167A allele ( P = 0.007). These findings suggested that signaling through IL-10R2 may play a causative role in dcSSc.