Osteoporosis and fractures in Turner syndrome-importance of growth promoting and oestrogen therapy

• Published in: Clinical endocrinology (Oxford) 1999-10, Vol.51 (4), p.497-502
• Main Authors: Landin-Wilhelmsen, Kerstin, Bryman, Inger, Windh, Marianne, Wilhelmsen, Lars
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Body Composition; Body Height; Body Mass Index; Body Weight; Bone Density; Case-Control Studies; Chromosome aberrations; Estrogen Replacement Therapy; Female; Fractures, Bone - blood; Fractures, Bone - etiology; Fractures, Bone - physiopathology; Growth Hormone - therapeutic use; Hearing Disorders - blood; Hearing Disorders - complications; Hearing Disorders - physiopathology; Humans; Insulin-Like Growth Factor I - analysis; Medical genetics; Medical sciences; Middle Aged; Osteocalcin - blood; Osteoporosis - blood; Osteoporosis - complications; Osteoporosis - physiopathology; Parathyroid Hormone - blood; Turner Syndrome - blood; Turner Syndrome - complications; Turner Syndrome - physiopathology
• ISSN: 0300-0664; 1365-2265
• DOI: 10.1046/j.1365-2265.1999.00841.x

OBJECTIVE Turner syndrome (TS) is a chromosomal aberration (45,X) characterized by endogenous oestrogen deficiency and short stature. The aim was to study body composition, bone mineral density, fracture frequency, social and life style factors and biochemical bone markers, as well as hormones, in adults with TS in comparison with a female random population sample. PATIENTS Seventy women with TS responded to questionnaires. They underwent physical examination, bone mineral density measurement with Dual Energy X‐ray Absorptiometry (DEXA) and blood sampling. Mean age was 31 ± 12 (range 16–71) years. A random population sample of women from the WHO MONICA Project, Göteborg (25–64 years) served as controls (n = 740). RESULTS Women with TS were shorter than the controls and had lower body weight and lean body mass (P