Synthesis of [ 123I]IBZM: a reliable procedure for routine clinical studies

The single photon emission computed tomography (SPECT) D 2/D 3 receptor radiotracer [ 123I]IBZM, is prepared by electrophilic radioiodination of the precursor BZM with high-purity sodium [ 123I]iodide in the presence of diluted peracetic acid. However, in our hands, the most commonly used procedure...

Full description

Saved in:
Bibliographic Details
Published in:Nuclear medicine and biology 1999-08, Vol.26 (6), p.661-665
Main Authors: Zea-Ponce, Yolanda, Laruelle, Marc
Format: Article
Language:English
Subjects:
[ 123I]IBZM
Benzamides - chemical synthesis
Biological and medical sciences
D 2 receptor radiotracer
Dopamine Antagonists - chemical synthesis
Indicators and Reagents
Investigative techniques, diagnostic techniques (general aspects)
Iodine Radioisotopes
Iodobenzamide
Medical sciences
Nervous system
Peracetic Acid
Pyrrolidines - chemical synthesis
Radionuclide investigations
SPECT
Tomography, Emission-Computed, Single-Photon
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The single photon emission computed tomography (SPECT) D 2/D 3 receptor radiotracer [ 123I]IBZM, is prepared by electrophilic radioiodination of the precursor BZM with high-purity sodium [ 123I]iodide in the presence of diluted peracetic acid. However, in our hands, the most commonly used procedure for this radiosynthesis produced variable and inconsistent labeling yields, to such extent that it became inappropriate for routine clinical studies. Our goal was to modify the labeling procedure, to obtain consistently better labeling and radiochemical yields. The best conditions found for the radioiodination were as follows: 50 μg precursor in 50 μL EtOH mixed with buffer pH 2; Na[ 123I]I in 0.1 M NaOH (
ISSN:0969-8051
1872-9614
DOI:10.1016/S0969-8051(99)00031-1